Aromatase and breast cancer

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The increased malignant phenotype was confirmed to be due to aromatase expression as the growth of orthotopic tumors regressed with systemic administration of an aromatase inhibitor. This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

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Aromatase inhibitors such as anastrozole and letrozole are highly effective suppressants of estrogen synthesis in postmenopausal women and are the most effective endocrine treatments for hormone receptor positive breast cancer in such women. Little is known of the molecular effects of these agents on human breast carcinomas in vivo. We randomly assigned primary estrogen receptor positive breast cancer patients to treatment with anastrozole or letrozole for 2 weeks before surgery.

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Jump to navigation. Advanced or metastatic breast cancer is cancer that has spread beyond the breast and regional lymph node areas. Breast cancer can progress to metastatic disease despite the person undergoing a range of therapies given after initial treatment, such as surgery, chemotherapy or radiation therapy.

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Describe the differences in study designs, clinical outcome, and safety data on aromatase inhibitors. Select the proper aromatase inhibitor based on a thorough understanding of the data that led to the specific indication for the drug. We examined published reports on the use of aromatase inhibitors in postmenopausal patients with hormone receptor-positive breast cancer.

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O lder women being treated for the most common form of breast cancer who took drugs called aromatase inhibitors for 10 years rather than the usual five had a lower risk of their cancer returning, particularly in the opposite breast, physicians reported Sunday at the annual meeting of the American Society of Clinical Oncology. In a randomized controlled trial, women were given the drug and a placebo. Thirteen of the women taking the drug for an additional five years developed breast cancer in the opposite breast during the study, compared with 31 taking the placebo; 55 and 68, respectively, developed a recurrence of cancer in the original breast.

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Aromatase inhibitors are a class of drug used to prevent cancer recurrence in postmenopausal women with estrogen receptor-positive breast cancer. They work by reducing estrogen levels in the body, making less of the hormone available to stimulate the growth of hormone-sensitive cancer cells. Three aromatase inhibitors approved for use by the U.

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Aromatase inhibitors anastrozole, letrozole and exemestane are hormone therapy drugs used to treat hormone receptor-positive breast cancer. Aromatase inhibitors are only used to treat postmenopausal women and some premenopausal women also getting ovarian suppression. Some common side effects are described below.

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News Sponsored. Cancer Type Breast Cancer. Gastrointestinal Cancer.

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